Steps for Setting up a Pharmaceutical Clean Room

Steps for Setting up a Pharmaceutical Clean Room

Posted 2 weeks, 6 days agoViewed 68 times

Clean rooms are vital to the pharmaceutical industry. These rooms create a safe workspace for handling medicinal products, which requires immense care. To avoid making dangerous mistakes, read these crucial steps for setting up a pharmaceutical clean room.

Implement Clean or Dirty Corridors

When designing a clean room, you can take a “dirty corridor” or “clean corridor” approach. The design you chose ultimately comes down to the products inside the facility. For example, if employees handle dusty, dry pharmaceuticals in the room, cross-contamination risks will likely be high. However, working with powdery or dusty substances in a room sustaining negative air pressure differential—aka, a clean corridor—can prevent those substances from escaping the area.

On the other hand, products with higher moisture content, such as liquids, will attract microorganisms. That said, building the clean room to support a positive air pressure differential—aka, a dirty corridor—prevents microorganisms from entering the clean room and causing contamination.

Design With the Right Materials

Clean room equipment such as benches and workstations must contain material that complies with good manufacturing practice (GMP) standards. Additionally, the material must be durable, easy to install, able to handle frequent cleaning, and capable of providing reliable performance so employees can get work done daily.

For this reason, aluminum and stainless steel are the two most common metals you’ll find throughout clean rooms—both in equipment and in the clean room structure itself. Thankfully, experts can create modular clean room components with tools such as Bosch aluminum extrusion profiles. Likewise, modular aluminum framing systems are popular for building clean room walls. Use this tip for building every surface in the clean room; when in doubt, always consider GMP standards.

Optimize Airflow Successfully

One of the most important steps for setting up a pharmaceutical clean room is figuring out the right airflow characteristics. In other words, you need to provide a means of proper airflow and filtration. It’s crucial for clean rooms to have the right air quality, so they need a ventilation system that provides them sufficient control of factors such as positive/negative pressure and humidity.

Likewise, the air filtration system has to provide the right level of airflow to accommodate the particles filling the clean room. Depending on how hazardous the particles in any given clean room’s air are, facilities can either prioritize fresh air or recirculated air for the work environment.

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